The Compact Linear e+^+e−^- Collider (CLIC): Physics Potential

The Compact Linear Collider, CLIC, is a proposed e$^+$e$^-$ collider at the TeV scale whose physics potential ranges from high-precision measurements to extensive direct sensitivity to physics beyond the Standard Model. This document summarises the physics potential of CLIC, obtained in detailed studies, many based on full simulation of the CLIC detector. CLIC covers one order of magnitude of centre-of-mass energies from 350 GeV to 3 TeV, giving access to large event samples for a variety of SM processes, many of them for the first time in e$^+$e$^-$ collisions or for the first time at all. The high collision energy combined with the large luminosity and clean environment of the e$^+$e$^-$ collisions enables the measurement of the properties of Standard Model particles, such as the Higgs boson and the top quark, with unparalleled precision. CLIC might also discover indirect effects of very heavy new physics by probing the parameters of the Standard Model Effective Field Theory with an unprecedented level of precision. The direct and indirect reach of CLIC to physics beyond the Standard Model significantly exceeds that of the HL-LHC. This includes new particles detected in challenging non-standard signatures. With this physics programme, CLIC will decisively advance our knowledge relating to the open questions of particle physics.Comment: Input to the European Particle Physics Strategy Update on behalf of the CLIC and CLICdp Collaboration

Measurement of σ(Hνeνeˉ)×BR(H→ZZ∗){\sigma(H\nu_e\bar{\nu_e})\times BR(H\rightarrow ZZ^\ast)} and Higgs production in ZZZZ fusion at a 1.4 TeV CLIC collider

This paper presents the potential measurement at 1.4 TeV CLIC of the cross-section (times branching ratio) of the Higgs production via $WW$ fusion with the Higgs subsequently decaying in $ZZ^\ast$, ${\sigma(H\nu_e\bar{\nu_e})\times BR(H\rightarrow ZZ^\ast)}$, and of the Higgs production via $ZZ$ fusion with the Higgs subsequently decaying in $b\bar{b}$, ${\sigma(He{^+}e{^-})\times BR(H\rightarrow b\bar{b})}$. For the $H\rightarrow ZZ^\ast$ decay the hadronic final state, ${ZZ^\ast\rightarrow q\bar{q}q\bar{q}}$, and the semi-leptonic final state, ${ZZ^\ast\rightarrow q\bar{q}l^+l^-}$, are considered. The results show that ${\sigma(H\nu_e\bar{\nu_e})\times BR(H\rightarrow ZZ^\ast)}$ can be measured with a precision of 18.3% and 6% for the hadronic and semi-leptonic channel, respectively. ${\sigma(He{^+}e{^-})\times BR(H\rightarrow b\bar{b})}$ can be measured with a precision of 1.7%. This measurement also contributes to the determination of the Higgs coupling to the $Z$ boson, $g_{H_{ZZ}}$.Comment: Talk presented at the International Workshop on Future Linear Colliders (LCWS14), Belgrade, Serbia, 6-10 October 201

Performance of the EUDET-type beam telescopes

Test beam measurements at the test beam facilities of DESY have been conducted to characterise the performance of the EUDET-type beam telescopes originally developed within the EUDET project. The beam telescopes are equipped with six sensor planes using MIMOSA26 monolithic active pixel devices. A programmable Trigger Logic Unit provides trigger logic and time stamp information on particle passage. Both data acquisition framework and offline reconstruction software packages are available. User devices are easily integrable into the data acquisition framework via predefined interfaces. The biased residual distribution is studied as a function of the beam energy, plane spacing and sensor threshold. Its standard deviation at the two centre pixel planes using all six planes for tracking in a 6\,GeV electron/positron-beam is measured to be (2.88\,\pm\,0.08)\,\upmu\meter.Iterative track fits using the formalism of General Broken Lines are performed to estimate the intrinsic resolution of the individual pixel planes. The mean intrinsic resolution over the six sensors used is found to be (3.24\,\pm\,0.09)\,\upmu\meter.With a 5\,GeV electron/positron beam, the track resolution halfway between the two inner pixel planes using an equidistant plane spacing of 20\,mm is estimated to (1.83\,\pm\,0.03)\,\upmu\meter assuming the measured intrinsic resolution. Towards lower beam energies the track resolution deteriorates due to increasing multiple scattering. Threshold studies show an optimal working point of the MIMOSA26 sensors at a sensor threshold of between five and six times their RMS noise. Measurements at different plane spacings are used to calibrate the amount of multiple scattering in the material traversed and allow for corrections to the predicted angular scattering for electron beams

Identification of suitable adjuvant for vaccine formulation with the Neospora caninum antigen NcSRS2.

The parasite Neospora caninum is the main cause of abortion in cattle in many countries around the world, so a vaccine is a rational approach method for the control of the disease. An effective vaccine should be able to prevent both, the horizontal and vertical transmission of N. caninum. In this study, the immune vaccinal response of the recombinant protein rNcSRS2 of N. caninum expressed in Pichia pastoris and formulated with water-in-oil emulsion, xanthan gum, and alum hydroxide was assessed in an experimental murine model. Groups of 10 Balb/c mice were subcutaneously inoculated with two doses of prNcSRS2 twenty-one days apart. After the second immunization, four mice from each group were euthanized, and splenocytes were stimulated ex vivo with recombinant protein. The IgG dynamics were evaluated by indirect ELISA, and the splenocytes cytokines transcription by qPCR. All groups elicited specific antibodies against prNcSRS2, with the water-in-oil group showing significantly (p .05) elevated titers compared to the other groups. The prNcSRS2 protein alone did not induce a significant ex vivo splenic transcription level of IFN-c, TNF-a, IL-4, IL-10, and IL-12 cytokines, except for IL-17A, and the adjuvant associations with the prNcSRS2 protein induced different cytokine transcription profiles. The water-inoil emulsion modulated the expression of TNF-a; the xanthan gum modulated IL-4, IL-10, and IL-12; and alum hydroxide modulated IFN-c, TNF-a, IL-4, IL-10, and IL-12. In conclusion, it was found that the association of the recombinant prNcSRS2 protein with different adjuvants induced different levels of specific antibody, and a distinct splenic cytokine profile in an adjuvant-dependent manner. The mechanisms of adjuvancity activity is complex, so adjuvant formulation may help in the design of efficient vaccine to control Neosporosis

Performance Evaluation of Multiple Cloud Data Centers Allocations for HPC

This paper evaluates the behavior of the Microsoft Azure G5 cloud instance type over multiple Data Centers. The purpose is to identify if there are major differences between them and to help the users choose the best option for their needs. Our results show that there are differences in the network level for the same instance type in different locations and inside the same location at different times. The network performance causes interference in the applications level, as we could verify in our results.This research received funding from the EU H2020 Programme and from MCTI/RNP-Brazil under the HPC4E project, grant agreement no. 689772. Experiments presented in this paper were carried out using the Grid'5000 testbed, supported by a scientific interest group hosted by Inria and including CNRS, RENATER and several Universities as well as other organizations (see https://www.grid5000.fr). Additional funding was provided by CAPES and Microsoft.Peer ReviewedPostprint (author's final draft